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5/8 inch (15.9mm): Can be used safely by people with more subcutaneous tissue, but at 90 degrees in leaner individuals, this length may reach muscle

With the exception of STEP 5 [40] and STEP 10 [42], which differed in trial duration, and STEP 8 [46], which included an active comparator (liraglutide), all trials followed a standardised 68-week treatment period

Lu, S.C., et al., Insulin and Glucocorticoid Dependence of Hepatic Gamma-Glutamylcysteine Synthetase and Glutathione Synthesis in the Rat Studies in Cultured-Hepatocytes and Invivo

In an interim analysis of the ongoing phase 3 Effect of Semaglutide in Subjects with Non-cirrhotic Non-alcoholic Steatohepatitis (ESSENCE) trial (NCT04822181), once-weekly semaglutide 2.4 mg demonstrated superiority versus placebo for improvement of histological activity and fibrosis in participants with MASH and moderate to advanced liver fibrosis 6

Levine, M., Rumsey, S

However, they can also occur sporadically without any known genetic predisposition (Evans et al., 2021)