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Patients with certain medical conditions, such as gastrointestinal issues (e.g., gastroparesis) or a history of pancreatitis, may not be good candidates for GLP-1 treatment

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In mouse models, dual agonism had superior efficacy for weight loss and glucose control compared to a GLP-1RA alone 9 , with additive effects of the GIPR proposed to act through signaling in beta cells 10 , alpha cells 11 , the CNS (central nervous system) 12,13 and adipocytes 14

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