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Inhibit or evade multidrug resistance P-glycoprotein in cancer treatment

For example, the pH-sensitive conjugated micelle system (PAH/RGX-104@PDM/PTX) that encapsulates the hepatic X-nuclear receptor (LXR) agonist RGX-104 and paclitaxel not only has excellent tumor accumulation and tumor penetration but also reduces the level of immunosuppressive MDSCs and significantly reduces tumor immunosuppression, enhances the anti-tumor effect of CTLs thereby inhibiting tumor growth in vivo ( 124)

In rabbit studies, GHK-Cu treatment was associated with wound contraction and granulation tissue formation

KPV directly inhibits NF-B nuclear translocation via competitive importin-3 binding, suppressing pro-inflammatory cytokine secretion at nanomolar concentrations in cell-based models

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