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Unlike bariatric surgery, medical weight loss programs focus on customized plans that include nutrition counseling, lifestyle coaching, and medications to support safe and sustainable results

thus, the addition of TMAO levels could improve existing risk stratification tools

In many cases, some level of queasiness is a part of how these drugs work

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its absence is informative but not disqualifying, especially when mechanistic and physiological evidence is otherwise robust ( Finally, insurmountable technical barrierssuch as inability to manufacture stable formulations, extreme immunogenicity, or lack of feasible delivery routesmay justify abandonment independent of biological plausibility

The clinical visit is not just for writing the prescription