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Main active components of Jiawei Gegen Qinlian decoction protects against ulcerative colitis under different dietary environments in a gut microbiota-dependent manner

Boehringer acquired the candidate in 2015 for up to 222.5 million (nearly $253 million) from Pharmaxis, which initially developed the drug as PXS-4728A

Its direct suppression of NF-kB, the master inflammatory transcription factor involved in psoriasis, gives it the strongest mechanistic rationale

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Research in fruit flies, mice and rats has yielded interesting results regarding increased lifespan

All compounds listed are supplied for laboratory research use only and are not intended for human use