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Bad News: Tolerability and Dropout Rates One of the biggest drawbacks has been the gastrointestinal distress caused by a GLP-1/glucagon dual agonist

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doi: 10.1089/jwh.2022.0132 136 GordonM

People with issues, like gastroparesis (delayed stomach emptying), should avoid semaglutide

Constipation: Gradually increase fiber intake

These are the Danish Data Protection Agency ( for phenotypic data from study participants recruited in Denmark, the Federal Commissioner for Data Protection ( for phenotypic data from study participants recruited in Germany and the Commission Nationale Informatique & Liberts ( for phenotypic data of study participants recruited in France