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Following centrifugation at 8000 g for 10 min, the OD at 532 nm was measured in the supernatant
39 Dungan et al analyzed data from PIONEER trials and found out that the proportion of patients achieving clinically relevant reductions in both HbA1c and body mass were significantly greater in the group treated with orally administered semaglutide versus comparators (liraglutide, empagliflozin, sitagliptin)
The inconsistent pattern in semaglutide exposure across renal function groups can be attributed to a lack of effect of renal impairment on semaglutide exposure, as was previously observed with subcutaneous semaglutide [15], together with the higher intrinsic variability of orally administered semaglutide
The Journal of Clinical Endocrinology & Metabolism 105, e2695e2709
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