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The plasma samples were diluted 100 and the assay conducted as per the manufacturers instruction

Pro-inflammatory adipokines (e.g., leptin, resistin) and adipose-derived exosomes (carrying miRNAs like miR-3074-5p) create a chronic inflammatory joint microenvironment by polarizing synovial macrophages toward an M1 phenotype and inhibiting anti-inflammatory adiponectin (1618)

Curcumin often refers to the 3 naturally-occurring curcuminoids: Demothoxycurcumin (also known as curcumin II) Bisdemethyooxycurcumin (also known as curcumin III) Curcumin (also known as cyclocurcumin) Collectively the three curcuminoids make up an average of 3 percent of turmeric as a whole and are responsible for most of the health benefits

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