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However, when HSL-deficient mice were produced and shown to efficiently hydrolyze triglycerides the model began to emerge demonstrating ATGL, and not HSL, to be rate-limiting for adipose tissue triglyceride hydrolysis

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Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice Each reference was checked against its PubMed record on 2026-07-28: the PMID resolves and the title, journal and year match

While treatments like retinoids and chemical peels have their place, they often come with potential side effects, including redness, peeling, and sun sensitivity