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There was no control group, no placebo arm, no blinding
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Furthermore, in light of more recent data on the possible effect of Se on insulin resistance and the risk for type 2 diabetes, the upper tolerable limit has been further reduced to 255 g/day by the latest EFSA recommendations from 2023 (51)
Reading the permeability data honestly The strongest data on 5-Amino-1MQs absorption come from the 2018 study by Neelakantan and colleagues, which characterized a series of methylquinolinium NNMT inhibitors the scaffold that includes 5-Amino-1MQ
In particular, there was a clear neuroprotective effect on the left CA1, dentate gyrus, and subiculum regions of the hippocampus, all showing a reduced atrophy rate compared to sham controls (Broadhouse et al., 2020)
trial data describe a characterized study drug, not the contents of a vial
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