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However, the timing of supplementation is critical to maximizing its benefits
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elegans strains were maintained on nematode growth medium (NGM) agar plates seeded with bacterial diet E
Group 5 indicated similar GR response to that of group 4, which remained significantly lower than the control (group 1) (Figure 6B)
Thus, like in other ciliopathy models (7, 15, 16), ablation of Bbs5 led to aberrant pancreatic morphology, defective insulin signaling, and impaired glucose homeostasis
This would be in line with preclinical observations that incretin receptor expression is down-regulated by exposure to high glucose, and improves once normoglycaemia is restored (48), and that dys-regulation of glycaemic control in otherwise healthy humans leads to impaired incretin actions (49)
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