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The activation of mixed lineage kinase domain-like protein (MLKL) by receptor-interacting protein 3 (RIPK3) is a key regulatory pathway of necroptosis, which disrupts cell membrane integrity and causes inflammation
Additionally, given the potential context-dependent effects of metabolites, findings obtained in a specific tumour type and with a specific ICB therapy cannot be directly translated to other settings and therefore require re-evaluation and validation
Antimelanogenic effects of curcumin and its dimethoxy derivatives: mechanistic investigation using B16F10 melanoma cells and zebrafish ( Danio rerio ) embryos
However, another systematic review including 17 observational studies and 17 RCTs failed to find evidence of a consistent association between the Mediterranean diet and gut microbiota metabolism and composition (93)
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