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Jamey Millar, Executive Vice President, US Operations, Novo Nordisk, said: For many older Americans living with obesity, this is a moment they and their families have been waiting for
The caveat
Studies suggest that KPVs anti-inflammatory mechanism is independent of melanocortin receptors and involves direct entry into cells, distinguishing it from full-length -MSH signaling
reported no significant effects on BMC, BMD or bone turnover markers (such as osteocalcin, CTX, IGF-1)
Oral capsules also eliminate sterility concerns and provide more accurate dosing than reconstituted solutions
Recently Novo Nordisk announced the initiation of REDEFINE 4, a phase 3 trial comparing CagriSema 2.4 mg with Lillys Zepbound 15 mg evaluating weight loss after 72 weeks in 800 obese patients non-diabetic and is expected to be completed by October 2025 (NCT06131437)
