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Its not a weight-loss drug
Most formulations are administered via subcutaneous injection, either daily or weekly, though oral semaglutide (Rybelsus) is also available for diabetes treatment
In trials, retatrutide produced larger average weight loss (about 24.2% at 48 weeks versus roughly 20.9% for tirzepatide at 72 weeks)
Each takes a different approach to the same fundamental problem, and understanding their distinct mechanisms helps you determine which one, or which combination, fits your situation
Epstein LH, Valoski A, Wing RR, McCurley J
1996;271:E808-13
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