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The 2026 review is blunt that diet is secondary, noting these measures are substantially less effective if dose titration is not actively and thoughtfully managed
No effects were seen when glucose was not administered, compatible with the idea that DPP-4 inhibition exerts an anti-hyperglycaemic effect by preventing degradation of endogenously released GLP-1 (26), subsequent studies in glucose-intolerant rodent models did show that the improved glycaemic control following in vivo DPP-4 inhibition was associated with enhanced intact GLP-1 responses to glucose challenges (2729)
10.3389/fendo.2021.721135 Front
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Gutzwiller JP, Gke B, Drewe J, Hildebrand P, Ketterer S, Handschin D et al
skin and joint studies on collagen peptides have typically measured outcomes at 8-12 weeks for early signals and 24 weeks or longer for structural changes
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