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Laboratory investigations have reported measurable changes in nitric oxide related signaling markers, endothelial migration assays, fibroblast gene expression profiles, and cytoskeletal reorganization markers in cell culture and animal models

It binds actin to influence cell motility and shape, promotes chemotaxis driving cell migration, enhances angiogenesis via cell surface ATP synthase interaction, and reduces inflammation through microRNA-146a upregulation

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Salgar's team used hydrogel to deliver MSCs and growth factors

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