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J Physiol

In: TSRA Primer of Cardiothoracic Surgery

Oral bioavailability has not been characterized, and the compound's heptapeptide structure (773.89 Da) makes oral activity less likely than for the smaller Dihexa (504.66 Da), though not impossible given its modified sequence

Age-related cohesion loss around centromeres, a significant contributor to errors in chromosome segregation, is exacerbated by ROS-induced oxidation and carbonylation of proteins essential for spindle formation and stability, thereby increasing the risk of aneuploidy in offspring [4, 38]

Preclinical studies report that it influences the formation of new blood vessels (angiogenesis) and the migration of fibroblasts in cell-culture models

The liver and mitochondria then lose their main defense against oxidative damage, allowing inflammation and toxin buildup to worsen