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Per a 2021 analysis published in Diabetes Obesity Metabolism , nearly 50% of patients on semaglutide report nausea.41 Side effects tend to be dose dependent and may lessen in intensity with ongoing treatment.42,43 An underlying cause for these GI complaints relates to one of the ways in which GLP-1 medications work, which involves delayed gastric emptying
exendin-asp3
Louis, MO: Saunders Elsevier
It sits alongside the broader appetite suppression it says most patients report within days of starting, with the effect peaking around days seven to ten and persisting as long as the medication is used
Some research suggests that the mechanism by which semaglutide reduces appetite may involve interactions with dopamine pathways in the brain's reward system
Theyll use the results to see how well the drug is working for you
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