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Finally, it is important to avoid strenuous physical activity immediately after receiving a B12 shot

Providers can advise patients on practical strategies for at-home injection, including rotation of sites to prevent lipohypertrophy (lumpy buildup of fatty tissue under the skin) or irritation

Label each vial with the reconstitution date so the 28-day limit is always visible

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Although clinical trials are limited, the evidence suggests that B12 injections at a dose of at least 500 g three times per week for 2 weeks are effective in relieving chronic low back pain

Switching concentrations without recalculating can result in significant overdosing or underdosing