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However, these mechanistic effects have not translated into clinically meaningful reductions in gastrointestinal adverse events, and tirzepatide retains a predominantly GLP-1-like, dose-dependent gastrointestinal safety profile in clinical trials

Every drug has its risks, no matter how tremendous its benefits may be, and sometimes it can take a while to uncover less obvious side effects

doi: 10.1002/dmrr.2662 135 KotzbeckPTaschlerUHaudumCFoesslISchoiswohlGBoulgaropoulosBet al

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If you move your dose a day early, note it in your log so you can track if it caused any different side effects