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However, current and next-gen obesity therapeutics have the potential to vastly improve health outcomes
The TRAVERSE trial, the first large randomized controlled study on testosterone replacement therapy, demonstrated that modest testosterone doses did not increase cardiovascular event risk in men aged 45-80
By enhancing satiety through increased endogenous GLP-1, CCK, and PYY while reducing ghrelin levels, these polyols may help consumers limit caloric intake and manage their weight more effective 3
Although investigations in animals are scarce, studies among humans have suggested that GLP-1 RAs directly mitigate the development of coronary atherosclerosis through several mechanisms (Table 1)
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Obesity Pipeline Overview Number of Assets by Phase Certain mature disease areas have many different commercialized therapeutic drug choices to meet myriad patient requirements, yet the obesity space is at a relatively early stage of development and served by a narrow set of therapeutic options
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