GLP-1 is an incretin hormone that stimulates insulin secretion in a glucose-dependent manner, reducing hypoglycaemia risk The hormone slows gastric emptying and suppresses appetite through receptors in the pancreas, brain, and gastrointestinal tract GLP-1 receptor agonists (semaglutide, liraglutide, dulaglutide) are MHRA-approved for type 2 diabetes and weight management Common side effects include nausea, vomiting, and diarrhoea due to delayed gastric emptying and altered gut motility Patients should seek urgent medical attention for severe abdominal pain with persistent vomiting, as this may indicate pancreatitis GLP-1 medications do not directly impair digestive enzyme production, and routine enzyme supplementation is not clinically indicated Table of Contents What Does GLP-1 Stand For
prausnitzii, and Lactobacillus spp., is advisable, with parallel attention to the overgrowth of proinflammatory taxa like Proteobacteria
Preclinical studies suggest that GLP-1 receptor signaling may also influence intestinal epithelial turnover, oxidative stress, and gut barrier integrity
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(N=54) published in the European Journal of Nutrition (2015) found that 1,000 mg/day of oral glutathione for six months increased blood glutathione levels by 30 to 35% versus baseline