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Severe gastrointestinal disease: Conditions like gastroparesis, inflammatory bowel disease, or severe GERD may be worsened by Ozempics effects on gastric emptying

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Due to its effect on gastric emptying, tirzepatide may reduce the absorption of oral medications, including oral contraceptives, requiring backup contraception after initiation and each dose escalation

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All individuals considering GLP-1 therapy must undergo comprehensive medical evaluation by licensed healthcare providers who can assess individual appropriateness based on complete medical history, current health status, medications, and personal circumstances