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family history, physical inactivity, high-risk ethnicity, poor diet, hypertension, dyslipidemia, PCOS, prior gestational diabetes, prediabetes, or cardiovascular disease All adults aged 45 or older, regardless of weight Children aged 10 or older with overweight or obesity and two or more risk factors, screened at puberty onset Pregnant individuals: gestational diabetes screening at 2428 weeks New in ADA 2026 Screen individuals initiating immune checkpoint inhibitors, PI3K inhibitors, mTOR inhibitors, or high-dose glucocorticoids, a significant new addition for oncology and transplant patients

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First, we assumed a uniform effect of the medications across all people with diabetes, even those who would not have been eligible for the cardiovascular outcome trials from which these effect estimates were derived