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Among them, the glutathione system made up of GSH, enzymes involved in GSH anabolism, and GSH-dependent antioxidant enzymes play a critical role in cardioprotection from oxidative stress and redox homeostasis [12,13,14]
The research rationale for a selective NNMT inhibitor is to interrupt exactly that diversion, so the cell keeps more of its NAD+ pool and can run its mitochondrial machinery again
Chen J, Ding Z, Peng Y, Pan F, Li J, Zou L, Zhang Y, Liang H
The biological significance of such a specific increase of PUFA in GCLM KO livers remains to be elucidated
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