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Clinical trials of sodiumglucose cotransporter 2 (SGLT2) inhibitors and glucagon-like peptide 1 (GLP1) receptor agonists have shown beneficial effects of these agents on kidney outcomes in patients with type 2 diabetes mellitus

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Growth hormone secretagogues as a class are on S2 because of the mechanistic potential to elevate growth hormone and downstream IGF-1, which are the same axes targeted by the banned growth hormone (S2.1) itself

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