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This distinction is required on the labels of research chemicals, and is what exempts them from regulation under parts 100-740 in Title 21 of the Code of Federal Regulations (21CFR)

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HPLC, LC-MS & Analytical Review HPLC documentation supports purity assessment

20b.2.3 Riboflavin, FMN and FAD in blood Plasma or serum concentration of riboflavin and its derivatives, FMN and FAD have been used in a few studies for assessment of riboflavin status