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PIONEER-6 showed that oral semaglutide significantly reduced HbA1c levels and body weight and was non-inferior to placebo in terms of safety

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Hazard ratios (HR) along with 95% confidence intervals (CI) were used to compare the time to the event rates of intestinal obstruction

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This improvement might stem from specific sphingomyelin (SM)-derived lipids in MPLs, which also correlated with reduced signs of macrophage infiltration in the WAT, indicating lower inflammation [25]