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IL-21 signaling in immunity

Stress Stress does not directly cause hives but can lower the reaction threshold in people already prone to them, priming mast cells for a stronger response to an otherwise tolerable trigger

Hepatocellular injury, meaning damage to liver cells, releases stored vitamin B12 into the blood, and chronic liver disease reduces the clearance that normally keeps levels in check

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This subset is called chronic spontaneous (or idiopathic) urticaria and is thought to involve an autoimmune component where the immune system activates mast cells without an external cause

213 More recent clinical trials have added to the evidence that omega-3 fatty acids have important benefits in CKD patients requiring hemodialysis