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Abstract Type 2 diabetes represents a growing challenge for global public health

Cheng, J

The PI3K/AKT pathway is constitutively activated in a large fraction of EAOCs, often initiated by intrinsic structural alterations such as PTEN loss or PIK3CA activating mutations [25]

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doi: 10.23736/S0026-4784.20.04615-8 164 SantanamNKavtaradzeNMurphyADominguezCParthasarathyS

In this population: Higher waist-to-hip ratio increased risk up to 7.7-fold (especially peri-menopausally) Greater body fat percentage, waist-height ratio, or visceral fat area each increased risk around 4-fold Higher body mass index (BMI) or waist circumference, each, increased risk almost 3-fold Because obesity is associated with significant changes in immunometabolic and hormonal parameters, it seems likely that the strength of these findings will be confirmed in other populations