For example, in a recent study, menopausal women with obesity or overweight lost more weight when tirzepatide was used along with HRT, and they had better cardiometabolic outcomes
Legislative proposals to amend the exclusion have been introduced in Congress (the Treat and Reduce Obesity Act, reintroduced in 2025) but have not passed as of April 2026
Hypogonadism is documented in 50 to 75% of men with advanced kidney disease and in most men on dialysis
For context, the interplay between hormones and peptide signaling during this transition is an active research area, including a peer-reviewed update in the National Library of Medicine examining estrogens and neuropeptides in postmenopausal women
Many patients starting tirzepatide wonder where they'll notice weight loss firstwhether in the face, abdomen, or elsewhere
It is an injectable drug that works by lowering blood sugar levels in the body