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Adjusting birth control : Some experiment with contraceptives under medical supervision to regain stability

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There have been concerns that GLP-1RAs may increase the risk of intestinal obstruction

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Biopsy-proven NASH : Patients with histologically confirmed NASH, particularly those with significant inflammation or early fibrosis (F1-F2), may be considered for off-label GLP-1 therapy, especially if they have failed lifestyle modification or have contraindications to other therapies like vitamin E or pioglitazone