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15-24% at diabetes doses), vomiting, diarrhea, constipation, and abdominal discomfort, which may be difficult to distinguish from neurogenic bowel dysfunction in MS patients [11] [3] Fatigue : Reported in clinical trials and potentially additive to MS-related fatigue, one of the most disabling MS symptoms Dizziness : May occur due to blood pressure changes or dehydration, overlapping with MS-related balance and vestibular symptoms Weight loss induced by tirzepatidewhile therapeutically beneficial for metabolic healthrequires monitoring in MS patients, as unintentional or excessive weight loss could affect mobility, muscle strength, and overall functional status
Victoza (18mg/3ml) dosage starts with 0.6 mg subcutaneous injection per day for at least 1 week
SURMOUNT-1 Trial Data for Tirzepatide The SURMOUNT-1 trial (N=2,539) tested tirzepatide, a dual GIP/GLP-1 receptor agonist, in adults with obesity but without type 2 diabetes
A true plateau requires sustained stability across multiple weeks, not just a bad weigh-in after a salty meal or a weekend of travel
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Those events occurred predominantly in patients who had experienced nausea, vomiting or diarrhoea leading to volume depletion
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