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J Neurochem 2006
While modern medications, such as combined oral contraceptives (COCs) for hyperandrogenism and metformin for insulin resistance, effectively target specific symptoms, they often come with limitations, including side effects like gastrointestinal issues from metformin and COCs (95), as well as an incomplete understanding of the complexities of PCOS, particularly concerning gut dysbiosis
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In addition, chronic but not acute GSH depletion by buthionine sulfoximine (BSO) recapitulated the iron-induced phenotype
Managing expectations for chronic versus acute conditions helps avoid disappointment
Energy output may be up, but the underlying adrenal weakness is overlooked
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