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Xiaodong Chen, Huazhong Agricultural University, China
Tocochromanol uptake into enterocytes is facilitated by several transporters, including Niemann-Pick C1 like 1 (NPC1L1), scavenger receptor class B type I (SR BI), and cluster of differentiation 36 (CD36)
SCFAs in turn, via receptors in the gut(the second brain ), send signals to the central nervous system with the purpose of modulating, in the physiological range, energy homeostasis, carbohydrate and lipid metabolism, and suppress inflammatory signals
To determine the solution structural model of the p53 TAD2 -FOXO4-DRI complex using NMR spectroscopy, we recorded several sets of NMR experiments on two types of complexes: 13 C, 15 N-labelled p53 TAD2 -FOXO4-DRI and 13 C, 15 N-labelled FOXO4-LRI D -p53 TAD2 (see methods)
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