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GPX4 is also known as phospholipid hydroperoxide and exists as cytosolic, mitochondrial, and nuclear isoforms
Given that all ZDHHC family members contain highly conserved DHHC catalytic structural domains, systematic off-target effect assessment must be performed in the design of selective inhibitors, a critical step that will effectively address the problem of non-specific inhibition caused by structural homology
Manual stimulation of the tails was performed next using the standardized stretch/rub maneuver followed by scoring according to the Bennett scale
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19 , e3001287 (2021)
C., Ochoa, A
