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Arteriosclerosis, thrombosis, and vascular biology

GLP-1R/GDF15 co-agonists largely preclinical pair GLP-1R activation with GFRAL-mediated hindbrain signaling, an appetite-suppressive pathway that is mechanistically non-overlapping with the GLP-1R satiety circuit

Gross KL, Wedekind KJ, Kirk CA

Matching timeline expectations to mechanism biology prevents premature abandonment

Yet, compounded GLP-1 medications may only be prescribed by a licensed provider and prepared by a compounding pharmacy when a clinically significant difference is identified for an individual patient