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Notably, acetyl-CoA synthetase 2 (ACSS2) has been identified as a lactoyltransferase that mediates lactylation and promotes tumor immune evasion [49]
Combined with the molecular weight argument (semaglutide is too large to easily cross biological barriers into milk) and the poor oral bioavailability (any swallowed semaglutide would be destroyed in the infant gut), the safety profile looks reassuring