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Triggers of elevated ceramide levels comprise hyperosmotic shock [122], secreted sphingomyelinases (SMases) during inflammation [125], sepsis [126] or severe coronavirus disease 2019 (COVID-19) [127], Clostridium perfringens epsilon toxin [128], and platelet-activating factor [129]
Free Radical Research, 2011
Tendon injuries are particularly well-suited to intervention because tendons have inherently limited blood supply, which slows natural healing
Symptoms may range from mild skin irritation to more severe symptoms like difficulty breathing and anaphylaxis
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