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Meanwhile, rarer safety concerns of CagriSema include gallbladder issues, hypoglycemia, or pancreatitisside effects associated with any GLP-1s
Additionally, patients taking insulin or sulfonylureas require dose adjustments of these medications when starting semaglutide to prevent hypoglycemia
The proposed mechanism involves potentiation of existing opioid tone rather than direct opioid receptor agonism, which may explain the absence of classical tolerance and dependence patterns
371 Elevated BBB permeability of the system was observed due to a combination of lactoferrin-mediated BBB transcytosis and photothermal effects
Nat Metab 7 , 13221329 (2025)
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