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A decline in insulin dose requirement could explain weight reduction after intensification with the dual agonist in this setting
As shortages of brand-name GLP-1 medications begin to ease, regulators are increasing scrutiny on these platforms to ensure patient safety and compliance, signaling a broader crackdown on unapproved or gray-market weight-loss treatments
Lazi A, Popovi J, Paunesku T, Woloschak GE, Stevanovi M (2020) Insights into platinum-induced peripheral neuropathycurrent perspective
TRIUMPH-1 (NCT05929066), the Phase 3 registration trial for the obesity indication, reported topline results on May 21, 2026 : average weight loss of 28.3% at 80 weeks at the highest dose in 2,339 participants, versus 2.2% on placebo, and 30.3% at 104 weeks among participants with a BMI of 35 or above who continued in a pre-specified extension
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