Ionizing radiation triggers the antitumor immunity by inducing gasdermin E-mediated pyroptosis in tumor cells
(6) Note that low levels of glutathione have been associated with higher risks of hepatitis, type 2 diabetes, Parkinsons disease, and cancer
In a study screening commercial and experimental CYP51A1 inhibitors for anti-cancer activity, only VFV, a compound with a bulky imidazole-oxadiazole core, showed potent anti-proliferative effects across multiple cancer cell types
doi:10.1038/sj.ijo.0801740 Mor MI, Kenley D
In vitro it has been found to have a low molecular stability with a half life of only 15 minutes due to the action of a specific aminopeptidase-like enzyme
Bioinformatics 31:33593361 Mahmood Q, Ahmad R, Kwak S-S et al (2010) Ascorbate and glutathione: protectors of plants in oxidative stress