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Setmelanotide (Imcivree) licensed for the treatment of obesity caused by specific rare genetic conditions (including pro-opiomelanocortin [POMC] deficiency and leptin receptor deficiency)
A standard protocol using 500mcg daily requires 3-4 vials monthly, costing approximately $100-200 monthly
Patients can expect to lose 9.6% of their body weight over approximately 68 weeks, or 1-2 pounds per week
Results depend on combining the drink with a calorie-controlled diet and regular exercise
As expected, the compound 2GLP-1RG s complex exhibited a remarkable similarity to GLP-1-bound structures in terms of G protein-binding interface, consistent with a common mechanism of G s protein engagement
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