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These effects are blunted by vagotomy and by pharmacological or genetic inactivation of the GLP-1R in vagal afferents
One approach is targeting one of the key elements of BAD pathophysiology: the lack of negative feedback inhibition on the bile acid synthesis from the small intestine
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Its safety and efficacy have not been determined
10.3389/FIMMU.2017.00531 97 KhanA.AliT.RehmanS
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