Across GLP-1 trials, about 60% of lost weight returns within the first year and roughly 75% returns over the longer curve, with the fastest regain in the early months. The semaglutide extension follows the same direction. The pattern reflects removal of appetite suppression after major weight loss
Changes in renal function may also occur in patients experiencing significant weight loss, as glomerular hyperfiltration associated with obesity improves
These reactions can be worse when glutathione is given through IV
Sugiura Y, Tamai Y, Tanaka H (1978) Selenium protection against mercury toxicity: high binding affinity of methylmercury by selenium-containing ligands in comparison with sulfur-containing ligands
doi: 10.1038/s41467-021-27766-8 62
A landmark brain imaging study using proton magnetic resonance spectroscopy (1H MRS) revealed a staggering 36% decrease in cortical glutathione levels in the brains of ME/CFS patients compared to healthy controls