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Forty-eight weeks of close monitoring generates substantial safety data, and the results were encouraging enough to move the compound into Phase 3 without significant design changes to the safety monitoring framework

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Berberine (BER) is a yellowish, crystalline, quaternary isoquinoline alkaloid that has been extracted from different Chinese herbs, such as Cortex phelloderm, Mahonia bealei and Rhizoma coptidis [18,19,20]

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Its also worth noting that individuals may experience different symptoms or levels of improvement from B12 injections, depending on their health status and B12 levels before injection