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Many people find that supporting their antioxidant levels helps manage the systemic stress that contributes to morning stiffness

This can interfere with other hormones, like leptin and ghrelin, which can impair gutbrain signaling and contribute to increased hunger signals

Deficiency is virtually unknown among healthy people in Western countries, although diseases and poor lifestyle habits may increase the risk

( Epub 2019/01/15 )

Neurochem Int 104:3448

However, the link between DSIP and sleep has never been further characterized, in part because of the lack of isolation of the DSIP gene, protein and possible related receptor