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Statistical analyses, including t-tests, were conducted using GraphPad Prism 6 software

GHK-Cu acts via dermal papilla stem cells and matrix

Copper serves as a cofactor in numerous enzymes involved in collagen and elastin synthesis

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Neuroprotection Emerging Evidence Evidence Rating: Emerging (Interesting animal data, limited scope) Neurological applications show promise but require more research: Dopaminergic system protection Peripheral nerve regeneration Traumatic brain injury Alcohol-related neurological damage The GABAergic system interactions and NO modulation provide mechanistic support, but this area needs more study

Surface coatings can reduce direct interactions with biological systems, while chelators can bind metal ions, preventing toxicity