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A 5 to 10% weight loss can lead to MASH resolution in humans [4] and in rodents [16]

TRIUMPH-1's prespecified 104-week extension (BMI 35 subgroup) showed average weight loss reaching 30.3% higher than the 28.3% at week 80

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Some patients actually prefer evening dosing because nauseaif it occurspeaks during sleep when they can rest

Tirzepatide: similar stepwise increases, beginning with a low weekly dose and advancing in 4-week intervals