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[73] As noted above, the completely synthetic laboratory synthesis of B 12 was achieved by Robert Burns Woodward and Albert Eschenmoser in 1972, though this process has no commercial potential, requiring more than 70 steps and having a yield well below 0.01%

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This small molecule offers potential advantages over the PTD-DBM peptide: better stability, easier manufacturing, potentially superior skin penetration, and a path through standard pharmaceutical clinical trials

the supporting context is summarized in Important Notes above